Flipped classroom based on objective structured clinical examinations analysis by undergraduate students of Pharmacology course from the Podiatry Degree improve their learning and assessment communication skills about medicines

Comunicación cartel con defensa oralWe aim to evaluate the impact of the individual and in-group analysis of OSCEs (filmed by other students) looking for correct and incorrect behaviours and contents in their learning of pharmacology. Summary of work and outcomes: A 5-year prospective study in which students of Pharmacology course from the Podiatry Degree analysed filmed OSCEs individually and in a group in a flipped classroom. Each group (max 5 students) analysed along 1 week a filmed OSCE, prepare a summary of correct and incorrect items related to clinical events, medicines uses, and people behaviours. The students presented their analysis results to the rest of the class. After each presentation, the other students of the class were encouraged to ask questions and after that, the students voluntarily answered a satisfaction survey. Result and Discussion: 405 students, 65.2% female, 20±5.3 years old were included. Students spend 13.4±5.4 h on making the filmed-OSCE analysis. The percentage of students satisfied with this way of studying pharmacology was 96.5%. OSCEs analysis by students increased their percentage of success in the final assessment in both OSCEs-related and OSCEs-non-related questions (+18.5% and +10.1%). Conclusion: Filmed Objective Structured Clinical Examinations analysis by undergraduate students on the Pharmacology course of Podiatry Degree improved their knowledge about medicines use and their communication skills during the assessment.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Implantación de un Sistema de Gestión de calidad Iso 9001:2000 en Ingelecprem, S.L.

Ingelecprem S.L., és una empresa ubicada al Maresme. En la mesura que les necessitats ho han anat exigint, amb el pas del temps, s’han anat incorporant nous recursos. L’activitat de la empresa està relacionada amb el disseny, estudi i emissió d’especificacions per a instal·lacions elèctriques, públiques i industrials, així com també legalitzacions de projectes i serveis complementaris sol·licitats pels seus clients. El treball ben fet, l’excel·lent qualitat dels seus treballs, preus competitius i bon servei, han estat les insígnies i objectius d’aquest grup de professionals, que, amb el seu treball i dedicació, han obtingut un bon creixement dintre del sector i el manteniment de clients fixes importants. Davant el futur immediat, existeix una certa preocupació a disposar d’un Estatus de Qualitat Certificada i Acreditada, que permeti afrontar amb veritable legitimitat l’accés a Clients de certa categoria, cada vegada més exigents als seus encàrrecs i contractes de serveis, sense oblidar la creixent competitivitat dels nous països incorporats a la Comunitat Europea

Agregado de valor a la producción de maní en el norte argentino

Buscando evaluar la factibilidad y viabilidad de instalar una fábrica productora de maní saborizado y con chocolate, con abastecimiento de materia prima local y comercialización en la Provincia de Salta- Argentina, se llevó a cabo el estudio de contexto, de mercado (contemplando las 5 fuerzas de Porter, plan de marketing, estudio y proyección de la demanda), técnico (albergando la diagramación y planificación del proceso productivo, maquinaria, logística externa e interna, lay out y dimensiones del proyecto), ambiental, y económico/ financiero (obteniendo precio de venta y costo unitario del producto, costos fijos, flujo de fondos y análisis de sensibilidad) del proyecto. Dando como resultado que con una inversión inicial de USD $420.121, contemplando maquinaria, instalaciones, bienes de uso, adquisición de terreno y construcción, se obtuvo dos flujos de fondo, uno con aportes propios y otro con inversionistas a una tasa de interés del 59,90$398.041 o -USD $409.324, una TIR del 10% o -16% y un periodo de repago en el año N°9 o N°10 respectivamente, lo que volvió al proyecto inviable económicamente, no así en lo que respecta al resto de los estudios que se demostró su factibilidad. En el análisis final se podrá observar datos a tener en cuenta para mejorar la viabilidad económica del proyecto

Metodología de evaluación continua en la asignatura de Fundamentos de Programación: un cambio de evaluación enfocado al desarrollo de competencias

El marco del Espacio Europeo de Educación Superior (EEES) y la implantación del Sistema de Crédito Europeo (ECTS) han motivado un cambio en el modelo educativo. De un modelo basado en clases magistrales se ha evolucionado hacia un modelo basado en el aprendizaje por competencias del alumnado. Esto implica un cambio en el sistema de evaluación. Este trabajo expone la experiencia negativa vivida el primer año de la asignatura de Fundamentos de la Programación (FP) en los nuevos Grados de Ingeniería Informática de la Escuela Técnica Superior de Ingeniería Informática (ETSII) de la Universidad de Sevilla (US). La experiencia negativa se produjo por una sobre-evaluación del alumnado fruto de una planificación de evaluación un tanto excesiva. Como consecuencia de esta experiencia negativa, se decidió realizar una nueva planificación de evaluación continua de competencias adquiridas. Esta planificación se está llevando a cabo en la actualidad y en este artículo presentamos las conclusiones parciales.SUMMARY -- The European Higher Education Area and the implantation of the European Credit Transfer System have promoted a change in the educational model and, hence, a change in the evaluation system. This paper describes the negative experience in the first year of the course Fundamentals of Programming in the new Computer Science Degrees at University of Seville. The negative experience has been an overevaluation of the students caused by an excessive evaluation planning. To overcome this negative experience, a new plan of continuous assessment of skills is planned. This plan is being implemented at present and the partial conclusions obtained are described in this paper.Peer Reviewe

Leveraging Hardware QoS to Control Contention in the Xilinx Zynq UltraScale+ MPSoC

The interference co-running tasks generate on each other’s timing behavior continues to be one of the main challenges to be addressed before Multi-Processor System-on-Chip (MPSoCs) are fully embraced in critical systems like those deployed in avionics and automotive domains. Modern MPSoCs like the Xilinx Zynq UltraScale+ incorporate hardware Quality of Service (QoS) mechanisms that can help controlling contention among tasks. Given the distributed nature of modern MPSoCs, the route a request follows from its source (usually a compute element like a CPU) to its target (usually a memory) crosses several QoS points, each one potentially implementing a different QoS mechanism. Mastering QoS mechanisms individually, as well as their combined operation, is pivotal to obtain the expected benefits from the QoS support. In this work, we perform, to our knowledge, the first qualitative and quantitative analysis of the distributed QoS mechanisms in the Xilinx UltraScale+ MPSoC. We empirically derive QoS information not covered by the technical documentation, and show limitations and benefits of the available QoS support. To that end, we use a case study building on neural network kernels commonly used in autonomous systems in different real-time domains.This work has been partially supported by the Spanish Ministry of Science and Innovation under grant PID2019-107255GB; the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 878752 (MASTECS) and the European Research Council (ERC) grant agreement No. 772773 (SuPerCom).Peer ReviewedPostprint (published version

Localized magnetoplasmon modes arising from broken translational symmetry in semiconductor superlattices

The electromagnetic propagator associated with the localized collective magnetoplasmon excitations in a semiconductor superlattice with broken translational symmetry, is calculated analytically within linear response theory. We discuss the properties of these collective excitations in both radiative and non-radiative regimes of the electromagnetic spectra. We find that low frequency retarded modes arise when the surface density of carriers at the symmetry breaking layer is lower than the density at the remaining layers. Otherwise a doublet of localized, high-frequency magnetoplasmon-like modes occurs.Comment: Revtex file + separate pdf figure

Una experiencia práctica reutilizando aspectos

Este art´ıculo cuenta nuestra experiencia obtenida tras haber realizado un proyecto utilizando la tecnolog´ıa de aspectos AspectJ, y plantearsenos el hecho de reutilizar los aspectos definidos en el mismo con un nuevo proyecto a desarrollar. En definitiva, comprobar de forma pr´actica el grado de reutilizaci´on que tienen los aspectos en distintas aplicaciones

Increase of Circulating Monocyte–Platelet Conjugates in Rheumatoid Arthritis Responders to IL-6 Blockage

Monocytes; Rheumatoid arthritis; TocilizumabMonocitos; Artritis reumatoide; TocilizumabMonòcits; Artritis reumatoide; TocilizumabPlatelets (PLT) bind to a significant percentage of circulating monocytes and this immunomodulatory interaction is increased in several inflammatory and autoimmune conditions. The therapeutic blockage of IL-6 with Tocilizumab (TCZ) alters PLT and the phenotype and function of monocytes in rheumatoid arthritis (RA). However, the relationship between monocyte–PLT conjugates (CD14+PLT+) and clinical and immunological variables and the regulation of this interaction by IL-6 blockage are still unknown. Here, we compared the presence of monocyte–PLT conjugates (CD14+PLT+) and membrane CD162 expression using flow cytometry, and, by ELISA, the markers of PLT activation (sCD62P and sCD40L) in healthy donors (HD) and patients with long-standing RA before TCZ (baseline). We found higher percentages and absolute counts of CD14+PLT+, and higher plasmatic levels of sCD62P and sCD40L but lower CD162 expression on monocytes from RA patients than those from HD. Additionally, the levels of CD14+PLT+ inversely correlated with inflammatory parameters. Interestingly, 95% of patients with lower percentages of CD14+PLT+ and only 63% of patients with higher percentages of CD14+PLT+ achieved a EULAR-defined response at four weeks (p = 0.036). After TCZ, the percentage of CD14+PLT+ increased in 92% of RA patients who achieved 12 w-remission (p < 0.001). Our results suggest that the binding of PLTs has a modulatory effect, accentuated by the increased binding of PLTs to monocytes in response to the therapeutic blockage of IL-6.This study is supported by Instituto de Salud Carlos III and Fondos FEDER (PI17/00072 and PI20/00184)

A Peptide/Fullerene Hybrid for Multivalent Recognition of E-Selectin

Molecular recognition through ligand-receptor interactions is a very important mechanism for metastatic processes. Among all of them, multivalent protein-carbohydrate interactions play a fundamental role in tumor cell-endothelial cell recognition processes. In particular, the interaction between SLex and SLea expressed in circulating tumor cells and proteins of the family of selectins, overexpressed in endothelial cells. Unlike tumor cells, vascular endothelial cells receptors are a stable target not subjected to genetic modifications. In addition, the elimination of a single endothelial cell involves the death of hundreds of tumor cells. Targeting endothelial receptors cells offers a high potential in tumor diagnosis and therapy. SLex and SLea are the natural ligands of selectins, but their complicated chemical synthesis and their low affinity for selectins made difficult to continue with their development. Recently, through "phase display" it was identified a simple peptide with a linear sequence of seven amino acids (Ile-Glu-Leu-Leu-Gln-Ala-Arg) called IELLQAR that interacts specifically with selectins. IELLQAR is a very simple compound, which can be synthesized using SPPS. IELLQAR can be functionalized and easily conjugated to fullerenes for its multivalent presentation. In addition, it can be combined with diagnostic and therapeutic agents. References [1] Smith, B. A. H.; Bertozzi, C. Nat. Rev. Drug Discov. 2021, 20, 217.243. [2] Fukuda, M. N. et al. Cancer Res. 2000, 60, 450-456 [3] (a) Ramos-Soriano, J. et al. Chem. Commun. 2016, 52, 10544-10546; (b) Ramos-Soriano, J. et al. J. Org. Chem. 2018, 83, 1727-1736.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

La interacción de procesos hidrológicos, químicos y microbiológicos en la formación de películas flotantes ricas en hierro en ambientes acuáticos de pH circumneutro

17 páginas.-- 3 figuras.-- 4 tablas.-- 53 referencias.-- Postprint (Versión editorial)[EN]: The direct contribution of microbial activity to the formation of iron-oxide minerals is difficult to prove in wetlands due to the high reactivity of solid iron phases with different compounds and the variety of redox processes that may occur at each oxic-anoxic boundary. Here, we propose an explanation for the formation of iron-oxide films in wetlands and groundwater seepage areas fed by sandy aquifers based on the interaction of hydrological, chemical and microbiological processes under circumneutral conditions. The presence of a floating iron-oxide film was found to create a boundary at the air-water interface that maintains a suboxic and slightly acidic environment below the film compared with the environments obtained in other free-film wetland areas. The water trapped below this film had an average pH of 6.1, was particularly poor in O2, HCO–3, Na+, Ca2+, Mg2+, K+, and Tot-S, and has high concentrations of Tot-P, Tot-Fe, NH+4 and Zn. The formation of a floating iron-oxide film was reproduced under anaerobic conditions after progressive enrichment through the incubation of natural sediment samples in the laboratory. Heterotrophic bacteria belonging to the genus Enterobacter were the dominant bacteria in the enrichments that resulted in the formation of a floating iron-oxide film. The X-ray diffraction patterns showed that the presence of two-line ferrihydrite was common to the iron-oxide films collected in both the natural environment and the laboratory cultures, whereas other iron-oxides (goethite and low-crystalline lepidocrocite) were observed only in the natural environment. This study highlights the role of ubiquitous bacteria, which are generally considered unimportant participants in iron-transformation processes in the environment, and the contribution of both biological and non-biological processes to iron oxidation in natural systems under circumneutral conditions.[ES]: En los humedales, es difícil probar que la actividad microbiana sea la responsable de la formación de óxido de hierro mineral debido, tanto a la gran reactividad del hierro en fase sólida con diferentes sustancias, como a la variedad de procesos redox que pueden ocurrir en cada interfase óxica-anóxica. El presente trabajo propone una explicación, basada en la interacción de procesos hidrológicos, químicos y microbiológicos en condiciones circumneutras, para explicar la formación de un film de óxido de hierro en humedales y manaderos donde aflora agua subterránea proveniente de acuíferos de arenas silíceas. Además, la presencia de un film de óxido de hierro que flota sobre la interfase agua-aire genera condiciones subóxicas y ligeramente ácidas en el agua que queda atrapada debajo, y que son muy distintas a otras zonas libres de film en el mismo humedal. Este agua atrapada bajo el film se caracterizó por presentar un pH medio de 6.1, una menor concentración de O2, HCO–3, Na+, Ca2+, Mg2+, K+, y S total, pero una mayor riqueza en P total, Fe total, NH+4 y Zn. La formación de un film flotante de óxido de hierro se reprodujo en el laboratorio, en condiciones anaeróbicas, tras el enriquecimiento progresivo de las muestras del sedimento natural que habían sido incubadas. En dichos enriquecimientos, donde se produjeron films flotantes de óxido de hierro, la bacteria dominante perteneció al género Enterobacter. Mediante difracción por rayos X, se encontró ferrihidrita con estructura en doble cadena, tanto en el film de muestras naturales como de cultivos de laboratorio. Además se encontraron otros tipos de óxidos minerales (goetita y lepidocrocita de pobre cristalización) sólo en las muestras naturales de film. El presente estudio muestra la relevancia de bacterias ubicuas, hasta ahora consideradas sin importancia en procesos naturales de transformación del hierro, y la participación tanto de procesos bióticos como abióticos en la oxidación del hierro en sistemas naturales sometidos a condiciones circumneutras.We are grateful to Han Golterman for his support and suggestions. We thank Lotte Fleskens and Christien van der Zwart for collaborating with the sediment collection and P-fractionation at the laboratory. This study was partially supported by the Spanish Ministry of Education and Science (CGL2004-03927-C02-01/BOS)Peer reviewe